A complete remote-control system for reliable preparation of [18F]altanserin
| Autor: | Robert B. Innis, Ping-Zhong Tan, Pradeep K. Garg, Dennis S. Charney, Ronald M. Baldwin, Robert Soufer |
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| Rok vydání: | 1999 |
| Předmět: |
Fluorine Radioisotopes
Radiation Chromatography Chemistry Microwave oven Key features law.invention Solvent chemistry.chemical_compound law Yield (chemistry) Azeotropic distillation Isotope Labeling Altanserin Calibration Solid phase extraction Ketanserin Radiopharmaceuticals Remote control Chromatography High Pressure Liquid |
| Zdroj: | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 50(5) |
| ISSN: | 0969-8043 |
| Popis: | A complete remote control system was constructed for production of the PET 5-HT2A ligand [18F]altanserin by nitro-for-fluoro exchange. Comparing with published methods, the key features include (1) conducting azeotropic distillation and nucleophilic displacement in an open vessel heated by a commercial microwave oven; (2) purifying the product by a single HPLC procedure and (3) removing HPLC solvent by solid phase extraction. The preparation took 114 min with 23% yield and high quality. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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