scAAV9-VEGF-165 inhibits neuroinflammatory responses and invasion of macrophages into the peripheral nervous system of ALS transgenic mice
| Autor: | Xuexiao Chen, Jingxu Zhai, Yaling Liu, Weisong Duan, Jianwen Ji, Ying Wang, Shuo Sun, Yuanyuan Liu, Hongying Cui |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Vascular Endothelial Growth Factor A
0301 basic medicine Pathology medicine.medical_specialty Nerve root Genetic Vectors Mice Transgenic Inflammation Pathogenesis Random Allocation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Amyotrophic lateral sclerosis Muscle Skeletal Injections Spinal Microglia business.industry Macrophages General Neuroscience Amyotrophic Lateral Sclerosis Anti-Inflammatory Agents Non-Steroidal Dependovirus medicine.disease Sciatic Nerve Vascular endothelial growth factor Disease Models Animal 030104 developmental biology medicine.anatomical_structure Spinal Cord nervous system chemistry Peripheral nervous system Female Sciatic nerve medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Brain Research Bulletin. 140:233-242 |
| ISSN: | 0361-9230 |
| DOI: | 10.1016/j.brainresbull.2018.05.006 |
| Popis: | Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that leads to paralysis and death within 3-5 years. Although the vast majority of studies have focused on vulnerable neurons, growing evidence has shown that non-neuronal cells contribute to the pathogenesis and disease progression. Here, we showed that intrathecal injection of scAAV9-VEGF at 60 days of age significantly reduced the number of microglia and inhibited the neuroinflammatory response in the CNS. Meanwhile, we found that administration of VEGF inhibited the invasion of macrophages into the PNS, including ventral nerve roots, sciatic nerves and muscles. Overall, our study indicated the anti-inflammation effect of VEGF in the CNS and PNS of ALS mice when delivered by intrathecal injection. |
| Databáze: | OpenAIRE |
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