| Autor: |
Izyan Mohd Idris, Sophia Rasheeqa Ismail, Eashwary Mageswaren, Niko Ovenden, Rajiv Chowdhury, Thomas A. W. Bolton, Rahman Jamal, Siti Hafizah Zulkiply, Ammu Kutty Radhakrishnan, Jason Crawte, Puteri Sofia Nadira Megat Kamaruddin, Nur Suffia Sulaiman, Siti Khairani Zainal Abidin, Abdul Kahar Abdul Ghapar, Mohd Fairulnizal Md Noh, Kauthaman A Mahendran, Alan Yean Yip Fong, John Danesh, Ahmad Wazi Ramli, Liew Houng Bang, Anwar Irawan Ruhani, Shazana Rifham Abdullah, Noel Thomas Ross, Aizai Azan Abdul Rahim, Angela M. Wood, Wan Rozita Wan Mahiyuddin, Kim Robin van Daalen, Sophie Weston, Nur Hayati Azizul, Lee Chuey Yan, Laryssa Amado, Yong Shih Mei, Azizan Ali, Mansor Yahya, Omar Ismail, Nor Hanim Mohd Amin, Aaron Ong Hean Jin, Gunavathy Muthusamy, Ank Michielsen, Emanuele Di Angelantonio, Saravanan Krishinan, Norfashihah Faridus, Adam S. Butterworth, Yusniza Yusoff, Mostafa Monower, Nur Azirah Md Yusof, Nur Najwa Farahin M Yusoff, Norhayati Mustafa Khalid |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Popis: |
Background Although the burden of premature myocardial infarction (MI) is high in Malaysia, direct evidence on the determinants of MI in this multi-ethnic population remains sparse. Objective The Malaysian Acute Vascular Events Risk (MAVERIK) study is a retrospective case-control study established to investigate the genomic, lipid-related, and other determinants of acute MI in Malaysia. In this paper, we report the study protocol and early results. Methods By June 2019, we had enrolled approximately 2500 patients with their first MI and 2500 controls without cardiovascular disease, who were frequency-matched by age, sex, and ethnicity, from 17 hospitals in Malaysia. For each participant, serum and whole blood have been collected and stored. Clinical, demographic, and behavioral information has been obtained using a 200-item questionnaire. Results Tobacco consumption, a history of diabetes, hypertension, markers of visceral adiposity, indicators of lower socioeconomic status, and a family history of coronary disease were more prevalent in cases than in controls. Adjusted (age and sex) logistic regression models for traditional risk factors indicated that current smoking (odds ratio [OR] 4.11, 95% CI 3.56-4.75; P30 kg/m2; OR 1.19, 95% CI 1.05-1.34; P=.009) were associated with MI in age- and sex-adjusted models. Conclusions The MAVERIK study can serve as a useful platform to investigate genetic and other risk factors for MI in an understudied Southeast Asian population. It should help to hasten the discovery of disease-causing pathways and inform regionally appropriate strategies that optimize public health action. International Registered Report Identifier (IRRID) RR1-10.2196/31885 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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