Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives
| Autor: | Han-Gui Wu, Feng Xu, Jun-Rong Jiang |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Article Subject
biology 010405 organic chemistry Chemistry General Chemistry biology.organism_classification 01 natural sciences Chloride Combinatorial chemistry In vitro 0104 chemical sciences Acylation HeLa lcsh:Chemistry 010404 medicinal & biomolecular chemistry lcsh:QD1-999 Elemental analysis medicine Proton NMR Mass spectrum Cancer cell lines medicine.drug |
| Zdroj: | Journal of Chemistry, Vol 2016 (2016) |
| ISSN: | 2090-9071 2090-9063 |
| Popis: | Several new 1-(4-diarylmethylpiperazine-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione derivatives were synthesized by acylation of 1-diarylmethylpiperazine with 2-(1H-indol-3-yl)-2-oxoacetyl chloride. Their structures were confirmed by1H NMR, IR, mass spectra, and elemental analysis. These compounds were further evaluated for their anticancer activity, and most of them were found to have moderate-to-potent antiproliferative activities against Hela, A-549, and ECA-109 cancer cell linesin vitro. |
| Databáze: | OpenAIRE |
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