P14.119 Clinical-radiological description of a retrospective series of patients diagnosed with stroke due to hypercoagulability associated with cancer
| Autor: | I. Esparragosa, D Moreno-Ajona, J Gallego Perez de Larraya, Eduardo Martínez-Vila, Rafael Valenti-Azcarate, C Toledano-Illan, P. Irimia Sieira |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Neuro Oncol Europe PubMed Central |
| ISSN: | 1523-5866 1522-8517 |
| DOI: | 10.1093/neuonc/noz126.354 |
| Popis: | OBJECTIVES To describe the clinical-radiological characteristics of a monocentric series of patients with stroke due to a state of hypercoagulability associated with cancer. MATERIAL AND METHODS We retrospectively reviewed the clinical, radiological and laboratory data of 32 patients diagnosed of ischemic stroke secondary to a state of hypercoagulability associated with cancer between 2007 and 2017. RESULTS 15/32 were women. The median age was 65 years (range: 48–82). In 4/32 patients, stroke led to the diagnosis of advanced stage cancer, and in 15/32 it occurred in the context of uncontrolled cancer progression. 24/32 patients had at least an additional vascular risk factor. Complementary tests were performed (blood analysis, carotid echo-Doppler, ECG-monitoring, echocardiogram) to rule out other aetiologies. 25/32 patients had acute ischemic lesions in 3 to 5 cerebrovascular territories. 23/32 had multiorgan infarctions in body CT. The D-Dimer was analysed in 14/32 patients, being elevated in 13/14 patients. Half of patients (16/32) suffered a recurrence of stroke in the first 4 weeks. Most frequently detected tumours were lung adenocarcinoma (11/32) and pancreatic adenocarcinoma (8/32). The median survival after the stroke was 1 month (range: 0.2–25 months). CONCLUSIONS Uncontrolled cancer may lead to a prothrombotic state that facilitates the development of strokes in multiple cerebrovascular territories. Recurrences are frequent despite anticoagulant therapy, and prognosis is poor because of the underlying cancer and stroke-related neurological deterioration. |
| Databáze: | OpenAIRE |
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