Prognostic value of CXCR4 and FAK expression in acute myelogenous leukemia
| Autor: | Pascale Flandrin, Amélie Duval, Nathalie Nadal, Jérôme Cornillon, Emmanuelle Tavernier-Tardy, Denis Guyotat, Lydia Campos |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Receptors CXCR4 Cancer Research Adolescent Biology CXCR4 Flow cytometry Focal adhesion Myelogenous medicine Humans CXC chemokine receptors Aged Aged 80 and over Univariate analysis medicine.diagnostic_test Cell adhesion molecule Hematology Middle Aged Flow Cytometry Prognosis medicine.disease Leukemia Myeloid Acute Leukemia Phenotype Oncology Focal Adhesion Protein-Tyrosine Kinases Immunology Cancer research Female Cell Adhesion Molecules |
| Zdroj: | Leukemia Research. 33:764-768 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2008.10.014 |
| Popis: | We analysed, by flow cytometry, the “adhesive” phenotype of acute myelogenous leukemia (AML) cells from 36 patients treated in our institution. In univariate analysis, the main prognostic factor for CR achievement was lower CXCR4 expression (p = 0.03). Overall survival (OS) was negatively influenced by higher CXC chemokine receptor 4 (CXCR4) (p = 0.01), very late antigen-4 (VLA-4) (p = 0.01), and focal adhesion kinase (FAK) expression (p = 0.04). Combination of these markers allowed to distinguish two prognostic groups: patients overexpressing 2 or 3 factors had a significantly shorter OS (p = 0.015). CXCR4, VLA-4 and FAK are new phenotypic markers which could be helpful to establish risk-stratified therapeutic strategies. |
| Databáze: | OpenAIRE |
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