Obstructive Sleep Apnea and Heart Rate Variability in Male Patients with Metabolic Syndrome: Cross-Sectional Study
| Autor: | Rezso Zoller, Marta Novak, Zsófia Lendvai, Anett Lindner, Csilla Zita Turányi, Andrea Dunai, Miklos Z. Molnar, Istvan Mucsi, Katalin Zsuzsanna Ronai, O. Véber, Adam Gyula Tabák, Julia Luca Szocs, Katalin Keresztes |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Cross-sectional study Polysomnography Endocrinology Diabetes and Metabolism Young Adult stomatognathic system Heart Rate Internal medicine Internal Medicine Humans Medicine Heart rate variability Aged Aged 80 and over Metabolic Syndrome Sleep Apnea Obstructive medicine.diagnostic_test business.industry Sleep apnea Middle Aged medicine.disease nervous system diseases respiratory tract diseases Obstructive sleep apnea Cross-Sectional Studies Ambulatory Electrocardiography Ambulatory Cardiology Physical therapy Metabolic syndrome business Electrocardiography |
| Zdroj: | Metabolic Syndrome and Related Disorders. 12:117-124 |
| ISSN: | 1557-8518 1540-4196 |
| Popis: | Obstructive sleep apnea (OSA) is often accompanied by the metabolic syndrome. Because both conditions are associated with depressed heart rate variability (HRV) separately, our aim was to study whether co-morbid OSA is associated with more reduced HRV in male patients with the metabolic syndrome.In this cross-sectional study, 35 men (age, 57±11 years) with the metabolic syndrome (according to International Diabetes Federation criteria) were included. OSA severity was defined by the apnea-hypopnea index (AHI). HRV was assessed by 24-hr ambulatory electrocardiographic monitoring. Standard deviation of all normal-to-normal RR intervals (SDNN), the high frequency power (HFP), and the ratio of low- to high-frequency power (LF/HF) were measured.There were 14, 6, and 8 cases of severe (AHI ≥30/hr), moderate (15/hr≤AHI30/hr), and mild (5/hr ≤AHI15/hr) OSA, respectively. Seven patients had no OSA. Patients with mild-moderate or severe OSA had reduced SDNN and HFP values compared to those without OSA. Increasing OSA severity was associated significantly with lower daytime LF/HF ratio [standardized β regression coefficient (β)=-0.362, P=0.043] and higher night/day LF/HF ratio (β=0.377, P=0.023) after controlling for age, duration of diabetes, and severity of metabolic syndrome.Co-morbid OSA is associated with decreased overall HRV, parasympathetic loss, and impaired diurnal pattern of sympathovagal balance that may further increase the cardiovascular vulnerability of male patients with the metabolic syndrome. The role of the HRV analysis in the risk assessment of these patients warrants further studies. |
| Databáze: | OpenAIRE |
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