Lipase-Catalyzed Regioselective Esterification of Rapamycin: Synthesis of Temsirolimus (CCI-779)

Autor:	Ping Cai, Jianxin Gu, Mark Edward Ruppen
Rok vydání:	2005
Předmět:	Sirolimus Antibiotics Antineoplastic Esterification Molecular Structure biology Stereochemistry Chemistry Organic Chemistry Regioselectivity Stereoisomerism Lipase Biochemistry Catalysis Temsirolimus Acylation biology.protein medicine Oncology drug Physical and Theoretical Chemistry medicine.drug
Zdroj:	Organic Letters. 7:3945-3948
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol0514395
Popis:	A lipase-catalyzed acylation of the immunosuppressant rapamycin with complete regioselectivity is described. The method was successfully applied to the synthesis of 42-hemiesters and temsirolimus (CCI-779), an investigational oncology drug.[reaction: see text]
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced9268025e4c88bc285d908443437dc https://doi.org/10.1021/ol0514395 Zobrazit plný text záznamu