The membrane-proximal external region of the human immunodeficiency virus type 1 envelope: dominant site of antibody neutralization and target for vaccine design
| Autor: | Marinieve Montero, Xin Wang, Nienke E. van Houten, Jamie K. Scott |
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| Rok vydání: | 2008 |
| Předmět: |
Molecular Sequence Data
Reviews Biology HIV Antibodies Gp41 Microbiology Epitope Virus Neutralization Neutralization Tests Humans Amino Acid Sequence Molecular Biology AIDS Vaccines Immunodominant Epitopes Antibodies Monoclonal biology.organism_classification Virology HIV Envelope Protein gp41 Infectious Diseases Immunization Lentivirus biology.protein HIV-1 Antibody Erratum |
| Zdroj: | Microbiology and molecular biology reviews : MMBR. 72(1) |
| ISSN: | 1098-5557 |
| Popis: | SUMMARYEnormous efforts have been made to produce a protective vaccine against human immunodeficiency virus type 1; there has been little success. However, the identification of broadly neutralizing antibodies against epitopes on the highly conserved membrane-proximal external region (MPER) of the gp41 envelope protein has delineated this region as an attractive vaccine target. Furthermore, emerging structural information on the MPER has provided vaccine designers with new insights for building relevant immunogens. This review describes the current state of the field regarding (i) the structure and function of the gp41 MPER; (ii) the structure and binding mechanisms of the broadly neutralizing antibodies 2F5, 4E10, and Z13; and (iii) the development of an MPER-targeting vaccine. In addition, emerging approaches to vaccine design are presented. |
| Databáze: | OpenAIRE |
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