Effects of osteopontin-enriched formula on lymphocyte subsets in the first 6 months of life: a randomized controlled trial
| Autor: | Bo Lönnerdal, Anne Staudt Kvistgaard, Yong mei Peng, Sharon M. Donovan, Christina E. West, Janet M Peerson |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Inflammation Monocytes Flow cytometry law.invention 03 medical and health sciences 0302 clinical medicine Immune system stomatognathic system Randomized controlled trial law Internal medicine Leukocytes medicine Humans Lymphocyte Count Osteopontin Milk Human medicine.diagnostic_test biology Chemistry Monocyte Infant Newborn Infant Flow Cytometry Infant Formula Lymphocyte Subsets Breast Feeding Phenotype 030104 developmental biology Endocrinology medicine.anatomical_structure Infant formula Immune System Pediatrics Perinatology and Child Health biology.protein Female medicine.symptom Breast feeding 030215 immunology |
| Zdroj: | Pediatric Research. 82:63-71 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1038/pr.2017.77 |
| Popis: | BackgroundHuman milk is rich in osteopontin (OPN), which has immunomodulatory functions.MethodsIn a randomized controlled trial, standard formula (SF) and the same formula with 65 mg of OPN/L (F65) or 130 mg of OPN/L (F130), representing ~50 and 100% of the OPN concentration in human milk, were compared. We examined frequencies and composition of peripheral blood immune cells by four-color immunoflow cytometry of formula-fed infants at ages 1, 4, and 6 months, and compared them with a breastfed (BF) reference group.ResultsThe F130 group had increased T-cell proportions compared with the SF (P=0.036, average effect size 0.51) and F65 groups (P=0.008, average effect size 0.65). Compared with the BF group, the monocyte proportions were increased in the F65 (P=0.001, average effect size 0.59) and F130 (P=0.006, average effect size 0.50) groups, but were comparable among the formula groups.ConclusionOPN in an infant formula at a concentration close to that of human milk increased the proportion of circulating T cells compared with both SF and formula with added OPN at ~50% of the concentration in human milk. This suggests that OPN may favorably influence immune ontogeny in infancy and that the effects appear to be dose-dependent. |
| Databáze: | OpenAIRE |
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