Transient and localized optogenetic activation of somatostatin-interneurons in mouse visual cortex abolishes long-term cortical plasticiity due to vision loss
| Autor: | Chris Van den Haute, Detlef Balschun, Samme Vreysen, Victor Sabanov, Veerle Baekelandt, Lutgarde Arckens, Isabelle Scheyltjens |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine genetic structures Stimulation Blindness Somatosensory system Optogenetic stimulation Functional Laterality Mice 0302 clinical medicine Cortex (anatomy) Cortical plasticity Visual Cortex Neuronal Plasticity General Neuroscience Long-term potentiation Adulthood medicine.anatomical_structure Female Original Article Anatomy Somatostatin Histology Somatostatin interneurons Mice Transgenic Sensory system Optogenetics Biology Eye Enucleation Dark exposure 03 medical and health sciences Channelrhodopsins Interneurons Neuroplasticity medicine Animals Early Growth Response Protein 1 fungi Optic Nerve Recovery of Function Disease Models Animal 030104 developmental biology Visual cortex Gene Expression Regulation Vibrissae Multimodal Sensory Deprivation Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Brain Structure & Function |
| Popis: | Unilateral vision loss through monocular enucleation (ME) results in partial reallocation of visual cortical territory to another sense in adult mice. The functional recovery of the visual cortex occurs through a combination of spared-eye potentiation and cross-modal reactivation driven by whisker-related, somatosensory inputs. Brain region-specific intracortical inhibition was recently recognized as a crucial regulator of the cross-modal component, yet the contribution of specific inhibitory neuron subpopulations remains poorly understood. Somatostatin (SST)-interneurons are ideally located within the cortical circuit to modulate sensory integration. Here we demonstrate that optogenetic stimulation of visual cortex SST-interneurons prior to eye removal decreases ME-induced cross-modal recovery at the stimulation site. Our results suggest that SST-interneurons act as local hubs, which are able to control the influx and extent of cortical cross-modal inputs into the deprived cortex. These insights critically expand our understanding of SST-interneuron-specific regulation of cortical plasticity induced by sensory loss. ispartof: Brain Structure and Function vol:223 issue:5 pages:2073-2095 ispartof: location:Germany status: published |
| Databáze: | OpenAIRE |
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