Vicinal bisheterocyclizations of alkynes via nucleophilic interception of a catalytic platinum carbene
| Autor: | Eric M. Ferreira, Paul Allegretti |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Molecular Structure
Chemistry chemistry.chemical_element General Chemistry Photochemistry Biochemistry Combinatorial chemistry Catalysis chemistry.chemical_compound Colloid and Surface Chemistry Nucleophile Cyclization Heterocyclic Compounds Alkynes Reactivity (chemistry) Platinum Carbene Methane Vicinal Ethers |
| Zdroj: | Journal of the American Chemical Society. 135(46) |
| ISSN: | 1520-5126 |
| Popis: | A novel platinum-catalyzed double heterocyclization of propargylic ethers is described. The transformation exploits the intermediacy of a key α,β-unsaturated carbene. The reactivity of this carbene is such that systems can be developed which avoid a complicating 1,2-hydrogen migration, allowing remarkable versatility in the selective syntheses of oxygen- and nitrogen-containing vicinal bis-heterocyclic compounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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