The potential of infant fMRI research and the study of early life stress as a promising exemplar
| Autor: | Jennifer H. Pfeifer, Damien A. Fair, Weili Lin, Wei Gao, Alice M. Graham, Philip A. Fisher |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Resting State Functional Connectivity MRI Brain development Infancy Cognitive Neuroscience Early life stress Developmental cognitive neuroscience behavioral disciplines and activities Article Task (project management) Neural Pathways Developmental neuroimaging medicine Humans medicine.diagnostic_test lcsh:QP351-495 digestive oral and skin physiology Brain Infant Magnetic Resonance Imaging Mental health Functional system 3. Good health Resting state functional connectivity MRI Natural sleep fMRI lcsh:Neurophysiology and neuropsychology nervous system Child Preschool Developmental neuroscience Female Psychology Functional magnetic resonance imaging Neuroscience human activities Stress Psychological psychological phenomena and processes Cognitive psychology |
| Zdroj: | Developmental Cognitive Neuroscience, Vol 12, Iss C, Pp 12-39 (2015) |
| ISSN: | 1878-9293 |
| DOI: | 10.1016/j.dcn.2014.09.005 |
| Popis: | Functional magnetic resonance imaging (fMRI) research with infants and toddlers has increased rapidly over the past decade, and provided a unique window into early brain development. In the current report, we review the state of the literature, which has established the feasibility and utility of task-based fMRI and resting state functional connectivity MRI (rs-fcMRI) during early periods of brain maturation. These methodologies have been successfully applied beginning in the neonatal period to increase understanding of how the brain both responds to environmental stimuli, and becomes organized into large-scale functional systems that support complex behaviors. We discuss the methodological challenges posed by this promising area of research. We also highlight that despite these challenges, early work indicates a strong potential for these methods to influence multiple research domains. As an example, we focus on the study of early life stress and its influence on brain development and mental health outcomes. We illustrate the promise of these methodologies for building on, and making important contributions to, the existing literature in this field. |
| Databáze: | OpenAIRE |
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