Modeling the Interaction Between the Intra-Aortic Balloon Pump and the Cardiovascular System: The Effect of Timing
| Autor: | S Stéphanie Schampaert, Nhj Nico Pijls, Lokien X. van Nunen, Pal Tonino, Marcel van 't Veer, Mcm Marcel Rutten, Frans N. van de Vosse |
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| Přispěvatelé: | Biomedische Technologie, RS: CARIM School for Cardiovascular Diseases, Cardiovascular Biomechanics |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Cardiac output medicine.medical_treatment Biomedical Engineering Biophysics Diastole Hemodynamics Bioengineering Balloon Biomaterials Ventricular contraction intra-aortic balloon pump (IABP) Afterload Internal medicine timing Medicine Humans Computer Simulation Intra-aortic balloon pump Aged lumped parameter model Aged 80 and over Intra-Aortic Balloon Pumping business.industry Models Cardiovascular General Medicine Middle Aged Myocardial Contraction Blood pressure Cardiology cardiovascular system Female business |
| Zdroj: | Asaio Journal, 59(1), 30-36. LIPPINCOTT WILLIAMS & WILKINS ASAIO journal, 59(1), 30-36. Lippincott Williams and Wilkins Ltd. |
| ISSN: | 1058-2916 |
| DOI: | 10.1097/mat.0b013e3182768ba9 |
| Popis: | Because of the large number of interaction factors involved, the effects of the intra-aortic balloon pump (IABP) have not been investigated deeply. To enhance its clinical efficiency and to better define indications for use, advanced models are required to test the interaction between the IABP and the cardiovascular system. A patient with mild blood pressure depression and a lowered cardiac output is modeled in a lumped parameter computational model, developed with physiologically representative elements for relevant components of circulation and device. IABP support is applied, and the moments of balloon inflation and deflation are varied around their conventional timing modes. For validation purposes, timing is adapted within acceptable ranges in ten patients undergoing IABP therapy for typical clinical indications. In both model and patients, the IABP induces a diastolic blood pressure augmentation as well as a systolic reduction in afterload. The support capabilities of the IABP benefit the most when the balloon is deflated simultaneously with ventricular contraction, whereas inflation before onset of diastole unconditionally interferes with ejection. The physiologic response makes the model an excellent tool for testing the interaction between the IABP and the cardiovascular system, and how alterations of specific IABP parameters (i.e., timing) affect this coupling. |
| Databáze: | OpenAIRE |
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