Quaternary ammonium chitosans: The importance of the positive fixed charge of the drug delivery systems
| Autor: | Anna Maria Piras, Ylenia Zambito, Denise Beconcini, Chiara Migone, Angela Fabiano |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
N-2-hydroxypropyl trimethyl ammonium chitosan
Biocompatibility In vitro studies Dimethylethyl chitosan 02 engineering and technology Review 010402 general chemistry 01 natural sciences Catalysis Diethylmethyl chitosan Ex vivo studies Quaternary carboxymethyl chitosan derivatives Trimethyl chitosan Inorganic Chemistry Chitosan lcsh:Chemistry chemistry.chemical_compound Drug Delivery Systems Ammonium Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy chemistry.chemical_classification Chemistry Organic Chemistry General Medicine Polymer Biodegradation 021001 nanoscience & nanotechnology Combinatorial chemistry 0104 chemical sciences Computer Science Applications Quaternary Ammonium Compounds lcsh:Biology (General) lcsh:QD1-999 Fixed charge Drug delivery 0210 nano-technology |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 6617, p 6617 (2020) International Journal of Molecular Sciences |
| Popis: | As a natural polysaccharide, chitosan has good biocompatibility, biodegradability and biosecurity. The hydroxyl and amino groups present in its structure make it an extremely versatile and chemically modifiable material. In recent years, various synthetic strategies have been used to modify chitosan, mainly to solve the problem of its insolubility in neutral physiological fluids. Thus, derivatives with negative or positive fixed charge were synthesized and used to prepare innovative drug delivery systems. Positively charged conjugates showed improved properties compared to unmodified chitosan. In this review the main quaternary ammonium derivatives of chitosan will be considered, their preparation and their applications will be described to evaluate the impact of the positive fixed charge on the improvement of the properties of the drug delivery systems based on these polymers. Furthermore, the performances of the proposed systems resulting from in vitro and ex vivo experiments will be taken into consideration, with particular attention to cytotoxicity of systems, and their ability to promote drug absorption. |
| Databáze: | OpenAIRE |
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