Geographic diversity of human immunodeficiency virus type 1: serologic reactivity to env epitopes and relationship to neutralization
| Autor: | David Callow, Chantapong Wasi, Douglas M. Watts, Mansur M. Garaev, Rachanee Cheingsong-Popov, Sunil Shaunak, Niel T. Constantine, Ionel V. Petrascu, Pontiano Kaleebu, Simon Beddows, Jonathan Weber, Charles F. Gilks |
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| Rok vydání: | 1992 |
| Předmět: |
Serotype
Immunogen Asia Molecular Sequence Data Enzyme-Linked Immunosorbent Assay V3 loop HIV Antibodies Virus Epitope Neutralization Epitopes Antigen Antibody Specificity Neutralization Tests Predictive Value of Tests Immunology and Allergy Humans Amino Acid Sequence biology Gene Products env Virology Antigenic Variation Europe Infectious Diseases Africa North America biology.protein HIV-1 Antibody Peptides |
| Zdroj: | The Journal of infectious diseases. 165(2) |
| ISSN: | 0022-1899 |
| Popis: | The antibody recognition of the major neutralization epitopes of human immunodeficiency virus type 1 (HIV-1) in 829 HIV-1-seropositive subjects from North America (106), Europe (241), Africa (342), and Asia (100) was investigated. Peptides derived from diverse published V3 loop sequences were used as antigen, and serum reactivity was detected by sensitive ELISAs. Antibody binding to peptides derived from the V3 loop sequence of HIV-1 isolates varies considerably depending on the geographic origin of the antibody and is associated with neutralization titer against homologous isolates. Serotype reactivity to peptides may be a simple and rapid approach to investigation of HIV-1 env diversity worldwide and may assist the choice of immunogen for development of future AIDS vaccines. |
| Databáze: | OpenAIRE |
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