Inflammatory Fibroid Polyp of the Small Intestine: Ultrastructural and Immunohistochemical Observations
| Autor: | Morton J. Robinson, Saul Suster, Arkadi M. Rywlin |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Cytoplasm Pathology medicine.medical_specialty Stromal cell Golgi Apparatus Ileum Biology Endoplasmic Reticulum Cell junction Pathology and Forensic Medicine Immunoenzyme Techniques Structural Biology medicine Humans Vimentin Aged Cell Nucleus Gastrointestinal tract Endoplasmic reticulum Intestinal Polyps medicine.disease Small intestine Ileal Neoplasms Microscopy Electron medicine.anatomical_structure Immunohistochemistry Muramidase Inflammatory fibroid polyp |
| Zdroj: | Ultrastructural Pathology. 14:109-119 |
| ISSN: | 1521-0758 0191-3123 |
| Popis: | The ultrastructural and immunohistochemical features of a primary tumor of the ileum showing the classic histologic features of an inflammatory fibroid polyp (IFP) of the gastrointestinal tract are presented. Ultrastructurally the proliferating cells showed a combination of fibroblastic and histio cytic features, with abundant rough endoplasmic reticulum and active production of collagen in many of the cells and long, dendritic cytoplasmic projections with large cytoplasmic vacuoles containing remnants of phagocytosed cellular debris in others. Immunohistochemical studies showed strong cytoplasmic positivity in the proliferating cells with vi mentin antibodies and scattered positivity with muramidase. Additional findings include the ultra structural demonstration of oligocilia and occasional primitive intercellular junctions. The findings in this case suggest that IFP may represent a proliferation of primitive submucosal stromal cells exhibiting incomplete fibrohistiocytic differentiation. |
| Databáze: | OpenAIRE |
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