Later paternal age and sex differences in schizophrenia symptoms
| Autor: | Julie W. Messinger, Mark Opler, Mary Perrin, Jill M. Harkavy-Friedman, Paul J. Rosenfield, Arielle D. Stanford, Karine Kleinhaus, Raymond R. Goetz, Dolores Malaspina, Nicole Learned |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Sex differences in schizophrenia Physiology macromolecular substances behavioral disciplines and activities Paternal Age Article Sex Factors Risk Factors mental disorders medicine Humans Age of Onset Psychiatry Biological Psychiatry Psychiatric Status Rating Scales Negative symptom Analysis of Variance Age Factors Paternal age Middle Aged medicine.disease Psychiatry and Mental health Increased risk Schizophrenia Female Schizophrenic Psychology Analysis of variance Age of onset Psychology |
| Zdroj: | Schizophrenia Research. 116:191-195 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2009.10.020 |
| Popis: | Advanced paternal age is consistently associated with an increased risk for schizophrenia, accounting for up to a quarter of cases in some populations. If paternal age-related schizophrenia (PARS) involves a distinct etiopathology, then PARS cases may show specific characteristics, vis-à-vis other schizophrenia cases. This study examined if PARS exhibits the symptom profile and sex differences that are consistently observed for schizophrenia in general, wherein males have an earlier onset age and more severe negative symptoms than females.Symptoms were assessed at baseline (admission) and during medication-free and treatment phases for 153 inpatients on a schizophrenia research unit, 38 of whom fulfilled operationally defined criteria for PARS (sporadic cases with paternal ageor = 35).Males and females with PARS had the same age at onset and a similar preponderance of negative symptoms, whereas the other (non-PARS) cases showed the typical earlier onset age and more severe negative symptoms in males. When medications were withdrawn, PARS cases showed significantly worse symptoms than non-PARS cases (higher total PANSS scores and positive, activation, and autistic preoccupation scores). However these symptoms globally improved with antipsychotic treatment, such that the differences between the PARS and other schizophrenia cases receded.The lack of sex differences in the age at onset and the greater severity of medication-free symptoms bolster the hypothesis that PARS has a distinct etiopathology. It also suggests that female sex does not exert a protective effect on the course of PARS, as it may in other forms of schizophrenia. |
| Databáze: | OpenAIRE |
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