Aflatoxin-induced hepatic injury in the African monkey
| Autor: | Elliot Alpert, Bheeshma Rajagopolan, Arne Serck-Hanssen |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Toxic hepatitis
Pathology medicine.medical_specialty Aflatoxin Necrosis Biology chemistry.chemical_compound Aflatoxins Fibrosis Internal medicine medicine Environmental Chemistry Eosinophilia Animals Aspartate Aminotransferases Mycotoxin General Environmental Science Hyperbilirubinemia Stomach Public Health Environmental and Occupational Health Histology Haplorhini medicine.disease Disease Models Animal medicine.anatomical_structure Endocrinology chemistry Liver medicine.symptom Chemical and Drug Induced Liver Injury |
| Zdroj: | Archives of environmental health. 20(6) |
| ISSN: | 0003-9896 |
| Popis: | Aflatoxin B1, fed to African monkeys (Cereopithecus aethiops) in doses of 0.01 to 1.0 mg daily until death, produced a consistent histological pattern of hepatic toxicity characterized by centrilobutar loss of stainable cytoplasm and necrosis with mid-zonal fatty change, but without hemorrhage, fibrosis, or bile-duct proliferation. This toxic hepatitis, induced for the first time in a primate by aflatoxin, is similar to that occasionally seen in man and was preceded by mild elevations of bilirubin concentration and serum glutamic oxaloacetic transaminase activity, reflecting hepatic necrosis. |
| Databáze: | OpenAIRE |
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