Sensory deviancy detection measured directly within human nucleus accumbens
| Autor: | Raymond J. Dolan, Hans-Jochen Heinze, Robert T. Knight, Marta I. Garrido, Stefan Dürschmid, Jürgen Voges, Tino Zaehle, Hermann Hinrichs |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Auditory perception
Adult Male therapy [Drug Resistant Epilepsy] Drug Resistant Epilepsy Deep brain stimulation Cognitive Neuroscience medicine.medical_treatment Deep Brain Stimulation physiopathology [Drug Resistant Epilepsy] Sensory system Nucleus accumbens Stimulus (physiology) Neuropsychological Tests 050105 experimental psychology Nucleus Accumbens 03 medical and health sciences Cellular and Molecular Neuroscience P3a 0302 clinical medicine Event-related potential mental disorders medicine Humans 0501 psychology and cognitive sciences ddc:610 Evoked Potentials 05 social sciences physiopathology [Anterior Thalamic Nuclei] Original Articles physiopathology [Nucleus Accumbens] medicine.anatomical_structure nervous system Acoustic Stimulation Anterior Thalamic Nuclei Scalp Auditory Perception physiology [Auditory Perception] Female Psychology Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes |
| Zdroj: | Cerebral Cortex Cerebral cortex 26(3), 1168-1175 (2015). doi:10.1093/cercor/bhu304 |
| DOI: | 10.1093/cercor/bhu304 |
| Popis: | Rapid changes in the environment evoke a comparison between expectancy and actual outcome to inform optimal subsequent behavior. The nucleus accumbens (NAcc), a key interface between the hippocampus and neocortical regions, is a candidate region for mediating this comparison. Here, we report event-related potentials obtained from the NAcc using direct intracranial recordings in 5 human participants while they listened to trains of auditory stimuli differing in their degree of deviation from repetitive background stimuli. NAcc recordings revealed an early mismatch signal (50-220 ms) in response to all deviants. NAcc activity in this time window was also sensitive to the statistics of stimulus deviancy, with larger amplitudes as a function of the level of deviancy. Importantly, this NAcc mismatch signal also predicted generation of longer latency scalp potentials (300-400 ms). The results provide direct human evidence that the NAcc is a key component of a network engaged in encoding statistics of the sensory environmental. |
| Databáze: | OpenAIRE |
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