Relationships of orientation discrimination threshold and visual acuity with macular lesions in age-related macular degeneration

Autor: Hecheng Zhang, Harold E. Bedell, Chaochao Nie, Jianliang Tong, Xiaoling Liu, Yating Yang, Bin Zhang, Haojie Fu, Yingdong Luo
Rok vydání: 2017
Předmět:
Male
Visual acuity
genetic structures
Vision
Visual Acuity
lcsh:Medicine
Social Sciences
Retinal Pigment Epithelium
Pathology and Laboratory Medicine
Diagnostic Radiology
Macular Degeneration
0302 clinical medicine
Medicine and Health Sciences
Psychology
Geriatric Ophthalmology
lcsh:Science
Immune Response
Tomography
Aged
80 and over
Multidisciplinary
Radiology and Imaging
Retinal Degeneration
Diabetic retinopathy
Middle Aged
Macular Lesion
Retinal Disorders
Female
Sensory Perception
Anatomy
medicine.symptom
Tomography
Optical Coherence
Research Article
medicine.medical_specialty
Imaging Techniques
Ocular Anatomy
Immunology
Drusen
Research and Analysis Methods
Retina
03 medical and health sciences
Signs and Symptoms
Ocular System
Diagnostic Medicine
Ophthalmology
Age related
medicine
Humans
Metamorphopsia
Discrimination threshold
Aged
Inflammation
business.industry
lcsh:R
Biology and Life Sciences
Macular degeneration
medicine.disease
eye diseases
Geriatrics
Macular Disorders
Lesions
030221 ophthalmology & optometry
Eyes
lcsh:Q
sense organs
business
Head
030217 neurology & neurosurgery
Neuroscience
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 9, p e0185070 (2017)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0185070
Popis: Purpose To measure visual acuity and metamorphopsia in patients with age-related macular degeneration (AMD) and to explore their relationship with macular lesions. Methods In this cross-sectional study, a total of 32 normal subjects (32 eyes) and 35 AMD patients (35 eyes) were recruited. They were categorized into 4 groups: normal, dry AMD, non-active wet AMD, and active wet AMD. Best-corrected visual acuity (BCVA) was measured using the Early Treatment Diabetic Retinopathy Study protocol. Metamorphopsia was quantified with the orientation discrimination threshold (ODT). Macular lesions, including drusen, sub-retinal fluid (SRF), intra-retinal fluid (IRF), pigmented epithelium detachment (PED), and scarring, were identified with spectral-domain optical coherence tomography (SD-OCT). A linear regression model was established to identify the relationships between the functional and structural changes. Results BCVA progressively worsened across the normal, dry AMD, non-active wet AMD, and active wet AMD groups (P < 0.001), and ODT increased across the groups (P < 0.001). The correlation between BCVA and ODT varied among the groups. The partial correlation between BCVA and ODT was −0.61 (P < 0.001). Linear regression showed that ODT significantly depended on IRF (β = 0.61, P < 0.001), SRF (β = 0.34, P = 0.003), and scarring (β = 0.26, P = 0.050), while BCVA significantly depended only on scarring (β = −0.52, P < 0.001), and IRF (β = −0.36, P = 0.016). Conclusions From dry AMD to active wet AMD, BCVA gradually worsened while ODT increased. The correlation between BCVA and ODT varied among these groups, indicating that AMD lesions affect them differently. ODT and BCVA should be used concurrently for better monitoring of the disease.
Databáze: OpenAIRE
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