Lung de-recruitment in the allergic asthma of obesity: evidence from an anatomically based inverse model
| Autor: | Jason H. T. Bates, David A. Kaminsky, Olivia J. Garrow, Francesca K. Martin, Ubong Peters, W. Gabe Tharp, Anne E. Dixon |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Applied Physiology. 134:356-364 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00540.2022 |
| Popis: | The increase in asthma associated with the obesity epidemic cannot simply be due to airway hyperresponsiveness from chronic lung compression because chronic lung compression is a feature of obesity in general. We therefore sought to investigate what other factors might be at play in the impaired lung function seen in obese individuals with asthma. We measured respiratory system impedance in four groups - Lean Control, Lean Allergic Asthma, Obese Control, and Obese Allergic Asthma - before and after administration of albuterol. Impedance measurements were fit with an anatomically based computational model of lung mechanics that represents the airway tree as a branching structure with a uniform degree of asymmetry and a fixed radius scaling ratio, , between branches of sequential order. The two model parameters that define the airway tree, and tracheal radius, varied only modestly between the four study groups, indicating relatively minor differences in airway caliber. In contrast, respiratory system elastance was 57, 34, 143, and 271 cmH |
| Databáze: | OpenAIRE |
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