Diagnostic challenges in multiple system atrophy
| Autor: | Evaldas Keleras, Indre Eitmonaite, Sandra Bauzaite, Ilona Kulakiene, Daiva Rastenyte, Diana Obelieniene |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty progressive aphasia multiple system atrophy Case Report Progressive supranuclear palsy 03 medical and health sciences 0302 clinical medicine Atrophy Aphasia medicine Dementia neurodegenerative diseases Pure autonomic failure FDG-PET Cerebellar ataxia business.industry Parkinsonism progressive supranuclear palsy medicine.disease 030104 developmental biology Disease Presentation MRA medicine.symptom business 030217 neurology & neurosurgery dementia MRI |
| Zdroj: | Neuropsychiatric Disease and Treatment |
| ISSN: | 1178-2021 1176-6328 |
| Popis: | Multiple system atrophy is a progressive neurodegenerative disorder that is characterized by autonomic failure, cerebellar ataxia and parkinsonism syndrome in various combinations. In spite of the presence of well-established clinical criteria for multiple system atrophy, ante-mortem diagnosis is difficult. In our case report, we present a 78-year-old female patient who presented with early progressive aphasia and severe autonomic dysfunction. Two years after appearance of the first symptoms, she fulfilled all the major criteria for probable multiple system atrophy with rapid progression. In addition, brain magnetic resonance imaging and fluorodeoxyglucose-positron emission tomography findings were more typical for progressive supranuclear palsy. Clinically differentiating multiple system atrophy from progressive supranuclear palsy and other similar neurodegenerative disorders may be challenging in all stages of the disease, especially with atypical disease presentation. |
| Databáze: | OpenAIRE |
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