Constrained analogues of the calcitonin gene-related peptide
| Autor: | Juha Hakala, J. Hermonen, M. Halme, S. Vihavainen, T. Valo, Ari M. P. Koskinen, P. Heino |
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| Rok vydání: | 1994 |
| Předmět: |
Models
Molecular Protein Conformation Calcitonin Gene-Related Peptide Molecular Sequence Data Biophysics Peptide Calcitonin gene-related peptide Biochemistry Protein Structure Secondary Structure-Activity Relationship Protein structure Structure–activity relationship Animals Amino Acid Sequence Disulfides Calcitonin receptor Receptor Molecular Biology Peptide sequence Lung chemistry.chemical_classification integumentary system Chemistry Cell Biology Peptide Fragments Rats nervous system Calcitonin Rabbits Peptides Adenylyl Cyclases Receptors Calcitonin Gene-Related Peptide |
| Zdroj: | Biochemical and biophysical research communications. 202(1) |
| ISSN: | 0006-291X |
| Popis: | The calcitonin gene-related peptide, CGRP, has potential medicinal use for instance as a vasodilator or in the regulation of bone metabolism. In this study new analogues of CGRP based on molecular modelling of active fragments were synthesised and tested. The analogues were found to have affinities for the receptor comparable to those seen for native CGRP. Two analogues were found to be agonists. The analogues give an insight to the bioactive conformation of CGRP as they were constrained by disulphide bridges. |
| Databáze: | OpenAIRE |
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