Nonlinear modulation of interacting between COMT and depression on brain function
| Autor: | L. Gong, C. He, Y. Yin, Q. Ye, F. Bai, Y. Yuan, H. Zhang, L. Lv, Z. Zhang, C. Xie |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Prefrontal Cortex Hippocampus Catechol O-Methyltransferase behavioral disciplines and activities 03 medical and health sciences Superior temporal gyrus 0302 clinical medicine Gyrus Cortex (anatomy) medicine Humans Prefrontal cortex 030304 developmental biology Depressive Disorder Major 0303 health sciences Polymorphism Genetic Catechol-O-methyl transferase medicine.diagnostic_test Middle Aged Magnetic Resonance Imaging Psychiatry and Mental health medicine.anatomical_structure Female Functional magnetic resonance imaging Psychology Neuroscience 030217 neurology & neurosurgery rs4680 |
| Zdroj: | European Psychiatry. 45:6-13 |
| ISSN: | 1778-3585 0924-9338 |
| Popis: | Background:The catechol-O-methyltransferase (COMT) gene is related to dopamine degradation and has been suggested to be involved in the pathogenesis of major depressive disorder (MDD). However, how this gene affects brain function properties in MDD is still unclear.Methods:Fifty patients with MDD and 35 cognitively normal participants underwent a resting-state functional magnetic resonance imaging scan. A voxelwise and data-drive global functional connectivity density (gFCD) analysis was used to investigate the main effects and the interactions of disease states and COMT rs4680 gene polymorphism on brain function.Results:We found significant group differences of the gFCD in bilateral fusiform area (FFA), post-central and pre-central cortex, left superior temporal gyrus (STG), rectal and superior temporal gyrus and right ventrolateral prefrontal cortex (vlPFC); abnormal gFCDs in left STG were positively correlated with severity of depression in MDD group. Significant disease × COMT interaction effects were found in the bilateral calcarine gyrus, right vlPFC, hippocampus and thalamus, and left SFG and FFA. Further post-hoc tests showed a nonlinear modulation effect of COMT on gFCD in the development of MDD. Interestingly, an inverted U-shaped modulation was found in the prefrontal cortex (control system) but U-shaped modulations were found in the hippocampus, thalamus and occipital cortex (processing system).Conclusion:Our study demonstrated nonlinear modulation of the interaction between COMT and depression on brain function. These findings expand our understanding of the COMT effect underlying the pathophysiology of MDD. |
| Databáze: | OpenAIRE |
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