Chlordiazepoxide Metabolism in Mice following Hepatic Irradiation

Autor:	Philip Littman, Kate Franke, Gerald H. Sokol, David J. Greenblatt, Jan Koch-Weser
Rok vydání:	1975
Předmět:	Male Pharmacology Time Factors Chemistry Chlordiazepoxide General Medicine Metabolism Radiation Effects Mice Liver Biological significance medicine Animals Hepatic irradiation Irradiation Biotransformation Drug metabolism medicine.drug
Zdroj:	Pharmacology. 13:248-251
ISSN:	1423-0313 0031-7012
Popis:	Biotransformation of chlordiazepoxide was studied in mice following a single 1000-rad dose of hepatic irradiation. Meabolic N-demethylation of chlordiazepoxide in irradiated mice was impaired when tested 3 days after irradiation. No such effect was observed in mice tested 3 weeks or 6 weeks after irradiation. Thus, hepatic irradiation appeared to produce short-lived, reversible impairment of drug-metabolizing function. The effect was small and of uncertain biological significance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cebe7686fbda64cd1ae279d83def9c60 https://doi.org/10.1159/000136911 Zobrazit plný text záznamu