A genome-wide association study for harness racing success in the Norwegian-Swedish coldblooded trotter reveals genes for learning and energy metabolism

Autor: Brandon D. Velie, Gabriella Lindgren, C. F. Ihler, Marina Solé, Eric Strand, Kim Jäderkvist Fegraeus, Maria K. Rosengren, Knut Røed
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Performance
Potential candidate
Genome-wide association study
Horse
HYPERKALEMIC PERIODIC PARALYSIS
SEQUENCE VARIANTS
OXIDATIVE STRESS
Genetics (clinical)
Genetics & Heredity
Genetics
Racehorse
04 agricultural and veterinary sciences
MUSCLE
MYOSTATIN GENE
symbols
language
Female
Life Sciences & Biomedicine
EARLY CAREER
Research Article
DMRT3 GENOTYPES
lcsh:QH426-470
Energy metabolism
Genomics
Norwegian
Biology
Significant snps
Polymorphism
Single Nucleotide
03 medical and health sciences
symbols.namesake
Quantitative Trait
Heritable
Genetic
Animals
Learning
Horses
Science & Technology
PHENOTYPIC PARAMETERS
0402 animal and dairy science
GAIT KEEPER MUTATION
040201 dairy & animal science
language.human_language
lcsh:Genetics
030104 developmental biology
Bonferroni correction
Evolutionary biology
Energy Metabolism
Genome-Wide Association Study
Zdroj: BMC Genetics
BMC Genetics, Vol 19, Iss 1, Pp 1-13 (2018)
ISSN: 1471-2156
Popis: Background Although harness racing is of high economic importance to the global equine industry, significant genomic resources have yet to be applied to mapping harness racing success. To identify genomic regions associated with harness racing success, the current study performs genome-wide association analyses with three racing performance traits in the Norwegian-Swedish Coldblooded Trotter using the 670 K Axiom Equine Genotyping Array. Results Following quality control, 613 horses and 359,635 SNPs were retained for further analysis. After strict Bonferroni correction, nine genome-wide significant SNPs were identified for career earnings. No genome-wide significant SNPs were identified for number of gallops or best km time. However, four suggestive genome-wide significant SNPs were identified for number of gallops, while 19 were identified for best km time. Multiple genes related to intelligence, energy metabolism, and immune function were identified as potential candidate genes for harness racing success. Conclusions Apart from the physiological requirements needed for a harness racing horse to be successful, the results of the current study also advocate learning ability and memory as important elements for harness racing success. Further exploration into the mental capacity required for a horse to achieve racing success is likely warranted. Electronic supplementary material The online version of this article (10.1186/s12863-018-0670-3) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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