Dynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso
| Autor: | Karim Derra, Innocent Valea, Odile Zampa, Zekiba Tarnagda, Hermann Sorgho, Tinga Robert Guiguemdé, Adama Kazienga, Seydou Diallo Nakanabo, Paul Sondo, Jean-Bosco Ouédraogo, Halidou Tinto |
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| Rok vydání: | 2015 |
| Předmět: |
plasmodium falciparum
Short Communication Mutant Drug Resistance Protozoan Proteins Single-nucleotide polymorphism Drug resistance Polymorphism Single Nucleotide pfcrt Antimalarials Chloroquine parasitic diseases Burkina Faso medicine Prevalence Humans Allele Malaria Falciparum Malaria plasmodium falciparum chloroquine resistance pfcrt lcsh:R5-920 biology chloroquine resistance business.industry lcsh:Public aspects of medicine fungi Wild type Membrane Transport Proteins lcsh:RA1-1270 Plasmodium falciparum General Medicine biology.organism_classification medicine.disease Virology Malaria Mutation lcsh:Medicine (General) business geographic locations medicine.drug |
| Zdroj: | The Pan African Medical Journal Pan African Medical Journal; Vol 21, No 1 (2015) The Pan African Medical Journal, Vol 21, Iss 101 (2015) |
| ISSN: | 1937-8688 |
| Popis: | We investigated the evolution of Pfcrt K76T mutation five years after the withdrawal of chloroquine in Burkina Faso. A total of 675 clinical isolates collected from October 2010 to September 2012 were successfully genotyped. Single nucleotide polymorphism in Pfcrt (codon 76) gene was analyzed. The prevalence of resistant Pfcrt 76T allele was 20.55%. There was a progressive decrease of the proportion of mutant type pfcrt T76 from 2010 to 2012 (X2=5.508 p=0.0189). Our results suggest a progressive return of the wild type Pfcrt K76 in Burkina Faso but the prevalence of the mutants Pfcrt T76 still remains high. |
| Databáze: | OpenAIRE |
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