Preoperative miRNA-208a as a Predictor of Postoperative Complications in Children with Congenital Heart Disease Undergoing Heart Surgery
| Autor: | Tal Tirosh-Wagner, Yoav Bolkier, Yael Nevo-Caspi, Omer Bar-Yosef, Amir Vardi, David Mishali, Keren Zloto, Gidi Paret |
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| Rok vydání: | 2019 |
| Předmět: |
Heart Defects
Congenital Male 0301 basic medicine medicine.medical_specialty Clinical variables Heart disease Pharmaceutical Science Preconditioning 030204 cardiovascular system & hematology 03 medical and health sciences Postoperative Complications 0302 clinical medicine Predictive Value of Tests Risk Factors Genetics medicine Humans Circulating MicroRNA Cardiac Surgical Procedures Adverse effect Genetics (clinical) miRNA Congenital heart disease Pediatric cardiac surgery business.industry Infant Biomarker Perioperative medicine.disease Serum samples Surgery MicroRNAs Treatment Outcome 030104 developmental biology Prediction of complications Child Preschool Molecular Medicine Biomarker (medicine) Original Article Female Cardiology and Cardiovascular Medicine business Clinical risk factor |
| Zdroj: | Journal of Cardiovascular Translational Research |
| ISSN: | 1937-5395 1937-5387 |
| DOI: | 10.1007/s12265-019-09921-1 |
| Popis: | Major perioperative cardiovascular events are important causes of morbidity in pediatric patients with congenital heart disease who undergo reparative surgery. Current preoperative clinical risk assessment strategies have poor accuracy for identifying patients who will sustain adverse events following heart surgery. There is an ongoing need to integrate clinical variables with novel technology and biomarkers to accurately predict outcome following pediatric heart surgery. We tested whether preoperative levels of miRNAs-208a can serve as such a biomarker. Serum samples were obtained from pediatric patients immediately before heart surgery. MiRNA-208a was quantified by RQ-PCR. Correlations between the patient's clinical variables and miRNA levels were tested. Lower levels of preoperative miRNA-208a correlated with and could predict the appearance of postoperative cardiac and inflammatory complications. MiRNA-208a may serve as a biomarker for the prediction of patients who are at risk to develop complications following surgery for the repair of congenital heart defects. |
| Databáze: | OpenAIRE |
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