miR‐671‐5p repressed progression of papillary thyroid carcinoma via TRIM14
| Autor: | Fang Liu, Wan-Ju Wang, Piao Liu, Yuan Yuan, Dong Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Medicine (General) tumor suppressor miR‐671‐5p law.invention Tripartite Motif Proteins Thyroid carcinoma Mice R5-920 Downregulation and upregulation Cell Movement Genes Reporter In vivo law Cell Line Tumor microRNA Animals Humans Medicine Neoplasm Invasiveness Tumor growth Thyroid Neoplasms Viability assay TRIM14 Luciferases Base Pairing Cell Proliferation Mice Inbred BALB C Base Sequence Cell growth business.industry Intracellular Signaling Peptides and Proteins General Medicine Xenograft Model Antitumor Assays Carcinoma Papillary Tumor Burden Gene Expression Regulation Neoplastic MicroRNAs Ki-67 Antigen Disease Progression Cancer research papillary thyroid carcinoma Suppressor business Signal Transduction |
| Zdroj: | Kaohsiung Journal of Medical Sciences, Vol 37, Iss 11, Pp 983-990 (2021) |
| ISSN: | 2410-8650 |
| Popis: | The pivotal role of dysregulated miRNAs in development of papillary thyroid carcinoma has been emphasized in recent research. miR‐671‐5p was previously documented to function as a tumor suppressor. However, the role and mechanism of miR‐671‐5p in progression of papillary thyroid carcinoma remain to be further studied. Data from functional assays indicated that forced expression of miR‐671‐5p decreased cell viability, repressed cell proliferation, migration, and invasion in papillary thyroid carcinoma cells. In vivo study showed that miR‐671‐5p overexpression inhibited tumor growth, downregulated Ki67, and decreased tumor volume and weight. Tripartite motif containing 14 (TRIM14) was verified as downstream target of miR‐671‐5p. The expression of TRIM14 was suppressed by miR‐671‐5p in papillary thyroid carcinoma. Overexpression of TRIM14 increased cell viability, and promoted the proliferation, migration, and invasion of papillary thyroid carcinoma. Moreover, TRIM14 counteracted the suppressive effect of miR‐671‐5p overexpression on papillary thyroid carcinoma cell growth. In conclusion, miR‐671‐5p repressed progression of papillary thyroid carcinoma through downregulation of TRIM14, providing a promising target for therapy of papillary thyroid carcinoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text