Mitochondrial function in sepsis: Respiratory versus leg muscle
| Autor: | Olav Rooyackers, Katarina Fredriksson |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Phosphocreatine Multiple Organ Failure Respiratory System Mitochondrion Critical Care and Intensive Care Medicine law.invention Sepsis Adenosine Triphosphate law Intensive care Internal medicine Respiratory muscle Animals Humans Medicine Lactic Acid Respiratory system Muscle Skeletal Leg Muscle fatigue business.industry Skeletal muscle Muscle Smooth medicine.disease Intensive care unit Mitochondria Surgery medicine.anatomical_structure Cardiology Energy Metabolism business Locomotion |
| Zdroj: | Critical Care Medicine. 35:S449-S453 |
| ISSN: | 0090-3493 |
| DOI: | 10.1097/01.ccm.0000278048.00896.4b |
| Popis: | Patients with sepsis-induced multiple organ failure often experience muscle fatigue in both locomotive and respiratory muscles. Muscle fatigue extends intensive care unit stay, mostly in the form of prolonged weaning from the ventilator, and the recovery period after intensive care unit treatment due to general muscle fatigue. Muscle mitochondria are the main determinant of muscle fatigue and fatigability. Derangements in mitochondrial function in locomotive muscles have been described extensively both in animal models and patients with sepsis. Also, in respiratory muscle, mitochondrial function and content are impaired during sepsis. However, in septic patients with multiple organ failure, in locomotive muscle, lower levels of energy-rich compounds accompany the decreased mitochondrial content, whereas in respiratory muscle, the decreased mitochondrial content has no effect on cellular energy metabolism. |
| Databáze: | OpenAIRE |
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