The Role of Lung Colonization in Connective Tissue Disease-Associated Interstitial Lung Disease
| Autor: | Bruno Laganà, Marta Innammorato, Roberta Di Rosa, Michela D'Ascanio, Dario Pizzirusso, Raffaele Sglavo, Francesco Scarso, Alessandra Pagliuca, Simonetta Salemi, Morgana Vermi, Alberto Ricci |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
High-resolution computed tomography QH301-705.5 high-resolution computed tomography Connective tissue autoimmune disease Microbiology behavioral disciplines and activities Article Pulmonary function testing 03 medical and health sciences 0302 clinical medicine Virology Pulmonary fibrosis medicine microbiota interstitial lung diseases connective tissue diseases pulmonary fibrosis lung function tests 030212 general & internal medicine Biology (General) Autoimmune disease Lung medicine.diagnostic_test business.industry Interstitial lung disease respiratory system medicine.disease Connective tissue disease respiratory tract diseases body regions medicine.anatomical_structure 030228 respiratory system Immunology business |
| Zdroj: | Microorganisms Volume 9 Issue 5 Microorganisms, Vol 9, Iss 932, p 932 (2021) |
| ISSN: | 2076-2607 |
| DOI: | 10.3390/microorganisms9050932 |
| Popis: | Connective tissue diseases (CTDs) may frequently manifest with interstitial lung disease (ILD), which may severely impair quality and expectation of life. CTD-ILD generally has a chronic clinical course, with possible acute exacerbations. Although several lines of evidence indicate a relevant role of infections in the acute exacerbations of CTD-ILD, little information is available regarding the prevalence of infections in chronic CTD-ILD and their possible role in the clinical course. The aim of the present retrospective study was the identification of lung microbial colonization in broncho-alveolar lavage from patients affected by stable CTD-ILD with radiologically defined lung involvement. We demonstrated that 22.7% of patients with CTD-ILD display microbial colonization by Pseudomonas aeruginosa, Haemophilus influenzae, and non-tuberculous mycobacteria. Moreover, these patients display a major radiologic lung involvement, with higher impairment in lung function tests confirmed in a multivariate logistic regression analysis. Overall, the present study provides new information on lung colonization during CTD-ILD and its possible relationship with lung disease progression and severity. |
| Databáze: | OpenAIRE |
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