Effect of Zibu Shenjing Fang () on Growth and Development of the Mouse with Kidney-essence Insufficiency and Study on the Mechanism
| Autor: | Ji-ping Shi, Jun-xiao Yao, Xiao-jun Su, Wen-hui Wang, Shi-lin Shen, Zhi-peng Qiang, Yu-ping Wang |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Jingui shenqi medicine.medical_specialty mechanism Body weight Mice Zibu Shenjing Fang Internal medicine kidney-essence insufficiency syndrome Dose group medicine Animals Renal Insufficiency Insulin-Like Growth Factor I Medicine(all) Kidney Traditional medicine business.industry Body Weight Low dose Serum growth hormone General Medicine Normal group General state medicine.anatomical_structure Endocrinology Growth Hormone business Drugs Chinese Herbal |
| Zdroj: | Journal of Traditional Chinese Medicine. 31(3):232-234 |
| ISSN: | 0254-6272 |
| DOI: | 10.1016/s0254-6272(11)60048-4 |
| Popis: | Objective To investigate effects of Zibu Shenjing Fang ( ) on growth and development of the mouse with insufficiency of kidney-essence and the mechanism. Methods Total 50 mice were randomly divided into a normal group, a model group, a Jingui Shenqi Wan ( ) group, a Zibu Shenjing Fang high dose group and a Zibu Shenjing Fang low dose group, 10 mice in each group. The kidney-essence insufficiency mouse model was established by use of threat-injuring the kidney combined with over-fatigue. At the same time of modeling, the mice in the model group were intragastrically administrated with saline 20 mL·kg −1 ·d −1 , in the Jingui Shenqi Wan group with suspension of the Jingui Shenqi Wan 2.7 g·kg −1 ·d −1 , in the Zibu Shenjing Fang high dose group with Zibu Shenjing Fang 20 g·kg −1 ·d −1 and in the Zibu Shenjing Fang low dose group with Zibu Shenjing Fang 10 g·kg −1 ·d −1 , for 21 consecutive days. The general state was observed, the body weight was weighted, and serum growth hormone (GH) and insulin-like growth factor-1 (IGF-1) contents were detected. Results Compared with model group, Zibu Shenjing Fang groups and Jingui Shenqi Wan group could improve manifestation of the mouse with kidney-essence insufficiency, increase body weight of the mouse and serum GH and IGF-1 contents, especially in the high dose group. Conclusion Zibu Shenjing Fang gives play to the function of tonifying the kidney and replenishing essence through regulating GH and IGF-1 levels, so as to influence growth and development of the mouse. |
| Databáze: | OpenAIRE |
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