The value of melatonin supplementation in postmenopausal women with Helicobacter pylori-associated dyspepsia
| Autor: | Marta Mędrek-Socha, Cezary Chojnacki, Jan Chojnacki, Paulina Konrad, Aleksandra Błońska |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Placebo 030226 pharmacology & pharmacy Gastroenterology Asymptomatic Helicobacter Infections Melatonin 03 medical and health sciences Follicle-stimulating hormone 0302 clinical medicine Internal medicine medicine Humans Dyspepsia Pantoprazole Aged Breath test medicine.diagnostic_test biology Helicobacter pylori business.industry Obstetrics and Gynecology General Medicine Middle Aged biology.organism_classification medicine.disease Menopause Postmenopause Treatment Outcome Reproductive Medicine Dietary Supplements Female medicine.symptom business 030217 neurology & neurosurgery medicine.drug Research Article |
| Zdroj: | BMC Women's Health |
| DOI: | 10.21203/rs.3.rs-31148/v3 |
| Popis: | Background Dyspeptic syndrome is particularly common in postmenopausal women in the form of epigastric pain. The aim of the study was to assess the role of melatonin in chronic dyspepsia in this group of women, and examine the role of Helicobacter infection. Methods The study comprised 152 subjects including 30 healthy women (Group I), 60 women with asymptomatic H.pylori infection (Group II), and 64 women with H. pylori infection with chronic dyspepsia (Group III). Endoscopic examination was performed, as well as histological assessment of gastric end duodenal mucosa, urease breath test (UBT-13C), and immunoenzymatic assessment of serum 17-β-estradiol, follicle stimulating hormone and melatonin, and urinary 6-sulfatoxymelatonin. In Group III, 14-day antibacterial treatment was introduced with pantoprazole, amoxicillin and levofloxacin followed a six-month treatment with placebo in 32 women (Group IIIa), and melatonin 1 mg/morning and 3 mg/at bedtime in the other 32 women (Group IIIb). Results No significant differences were found between serum level of female hormone. Serum melatonin levels were similar between Group I (12.5 ± 2.72 pg/ml) and Group II (10.5 ± 3.73 pg/ml; p > 0,05). The level was significantly lower in Group III (5.72 ± 1.42 pg/ml; p H.pylori was obtained in 75.0% women in Group IIIa, and in 84.3% in Group IIIb (p > 0.05). After six months, dyspeptic symptoms resolved in 43.7% patients in Group IIIa and 84.3% in Group IIIb (p Conclusion Melatonin supplementation is useful in treating H. pylori-associated dyspepsia, particularly in postmenopausal women with lower levels of this hormone. Trial registration NCT04352062, date of registration: 15.04.2020. |
| Databáze: | OpenAIRE |
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