Immunohistochemical expression of K6, K8, K16, K17, K19, maspin, syndecan-1 (CD138), α-SMA, and Ki-67 in ameloblastoma and ameloblastic carcinoma: diagnostic and prognostic correlations
| Autor: | Rima A. Safadi, Basma F. Quda, Huda M. Hammad |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty government.form_of_government Pathology and Forensic Medicine Syndecan 1 Ameloblastoma 03 medical and health sciences 0302 clinical medicine Stroma Biomarkers Tumor Humans Medicine Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) Serpins biology business.industry Carcinoma Maspin 030206 dentistry Prognosis medicine.disease SMA Immunohistochemistry Jaw Neoplasms Actins Ameloblastic carcinoma Ki-67 Antigen 030220 oncology & carcinogenesis Ki-67 government biology.protein Keratins Surgery Syndecan-1 Neoplasm Recurrence Local Oral Surgery business |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 121:402-411 |
| ISSN: | 2212-4403 |
| DOI: | 10.1016/j.oooo.2015.11.015 |
| Popis: | To identify cutoff values of markers that correlate with the histopathologic diagnosis of ameloblastic carcinoma (AC) and/or the increased recurrence potential of ameloblastoma (AB).Immunohistochemical expression (IHCE) of 9 selected markers were investigated in 18 non-recurrent ameloblastomas (NRABs), 6 recurrent ameloblastomas (RABs), and 5 ACs.No significant difference in IHCE of K6, K8, K16, K17, K18, K19, maspin, or syndecan-1 was observed among study groups. α Smooth muscle actin (α-SMA)-positive area in central epithelial cells significantly differentiated between AB and AC (P = .017; t -test). Ki-67 score significantly differentiated between AB and AC (P.005; t -test) and between AC and RAB (P = .015; ANOVA/post hoc).Ki-67 score of 75 cells/HPF (ROC curve) is a potential indicator of AC. Clinical recurrence of AB may be predicted by α-SMA expression pattern. Syndecan-1 and α-SMA may indicate a higher aggressive potential of AB when expressed in the stroma. |
| Databáze: | OpenAIRE |
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