Cardiovascular responses to long-term blockade of nitric oxide synthesis
| Autor: | Lufei Hu, R. D. Manning, M. W. Norton, H. L. Mizelle, Jean-Pierre Montani |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Nitroprusside
Bradycardia medicine.medical_specialty Sodium chemistry.chemical_element Blood Pressure Pressoreceptors Arginine Nitric Oxide Iliac Artery Blood Urea Nitrogen Nitric oxide Phenylephrine chemistry.chemical_compound Basal (phylogenetics) Dogs Heart Rate Internal medicine Internal Medicine Animals Medicine business.industry Water-Electrolyte Balance Acetylcholine Blockade NG-Nitroarginine Methyl Ester Endocrinology Blood pressure chemistry Regional Blood Flow Creatinine Hypertension Potassium Amino Acid Oxidoreductases Nitric Oxide Synthase medicine.symptom business medicine.drug |
| Zdroj: | Hypertension. 22:40-48 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.22.1.40 |
| Popis: | The goal of this study was to determine if there is a basal release of nitric oxide that affects long-term arterial pressure regulation in dogs. Studies were conducted over a 23-day period in eight conscious dogs with indwelling catheters. Nitric oxide synthesis was blocked by continuous intravenous infusion of nitro-L-arginine-methyl ester at 37.1 nmol/kg per minute for 11 days. Arterial pressure increased to 120 +/- 4% of control on the first day, decreased for a few days, and then increased to a maximum value of 122 +/- 6% of control on day 7. Bradycardia was sustained throughout the entire nitro-arginine period. Blockade of nitric oxide synthesis was evidenced by attenuated pressure and flow responses to systemic acetylcholine infusion. The pressor response to phenylephrine was increased for only 1 day, and the hypotensive effects of nitroprusside were enhanced. Also, the variability of arterial pressure was significantly increased during nitro-arginine. Sodium and water balances were positive the first day of nitro-arginine infusion but were unchanged for the entire nitro-arginine period. In conclusion, the data suggest that blockade of the basal release of nitric oxide in dogs causes an increase in the long-term level of arterial pressure without any sustained sodium or water retention. |
| Databáze: | OpenAIRE |
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