Comparison of abbreviated modification of diet in renal disease formula (aMDRD) and the Cockroft-Gault adjusted for body surface (aCG) equations in stable renal transplant patients and living kidney donors
| Autor: | N. Shaheen, S. Khashab, Ahmed Fathy, Amin R. Soliman |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Urology Renal function Disease urologic and male genital diseases Critical Care and Intensive Care Medicine Young Adult Internal medicine Body surface medicine Living Donors Humans In patient Renal Insufficiency Chronic Intensive care medicine Kidney Transplantation business.industry General Medicine Middle Aged Models Theoretical Prognosis Kidney Transplantation Diet Endocrinology medicine.anatomical_structure Nephrology Renal transplant Female business Algorithms Glomerular Filtration Rate |
| Zdroj: | Renal failure. 35(1) |
| ISSN: | 1525-6049 |
| Popis: | The performance of abbreviated modification of diet in renal disease formula (aMDRD) and the Cockroft-Gault adjusted for body surface (aCG) equations as compared with measured 125I-iothalamate glomerular filtration rate was analyzed in patients with stable renal transplantation (RTx) and in potential living kidney donors (LKD). One hundred and thirty-one patients had RTx and 150 were LKD. The paired t-test showed that the estimated glomerular filtration rate (GFR) values through the aMDRD and the corrected CG equations were significantly different from each other (p0.01). There were significant differences between GFRs estimated using aCG and aMDRD equations (p0.001) in both groups (RTx and LKD) of different ages. The Pearson correlation coefficient between aCG and aMDRD equations was good (0.77, p0.01), but the kappa coefficient was 0.39, indicating a low agreement between the two formulae. In RTx patients with GFR60 mL/min/1.73 m2, the aMDRD equation performed better than the aCG formula with respect to bias (-0.6 vs. 3.0 mL/min/1.73 m2, respectively) and accuracy within 30% (72% vs. 56%, respectively) and 50% (91% vs. 73%, respectively). Similar results are reported for 48 diabetic RTx patients. In the LKD, the aMDRD equation significantly underestimated the measured GFR when compared with the aCG formula, with a bias of -8.0 versus 2.2 mL/min/1.73 m(2), respectively (p0.05). We can conclude that the Cockroft and MDRD equations cannot be used interchangeably in clinical transplantation practice and in order to adjust drug doses. |
| Databáze: | OpenAIRE |
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