miRNA-223 at the crossroads of inflammation and cancer
| Autor: | Wenqing Zhou, Jacob Jeffries, Qing Deng, Alan Y. Hsu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Carcinogenesis Inflammation Biology medicine.disease_cause Exosomes Article 03 medical and health sciences Extracellular Vesicles 0302 clinical medicine Neoplasms microRNA medicine Tumor Microenvironment Humans Tumor microenvironment Cancer Oncomir medicine.disease Microvesicles MicroRNAs 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer cell Cancer research medicine.symptom |
| Zdroj: | Cancer Lett |
| Popis: | miR-223 is an evolutionarily conserved anti-inflammatory microRNA primarily expressed in myeloid cells. miR-223 post-transcriptionally regulates many genes essential in inflammation, cell proliferation, and invasion. Recent studies show that miR-223 is either endogenously expressed or transferred in exosomes or extracellular vesicles to non-phagocytic cells including cancer cells, where it exerts biological functions. In cancerous cells, miR-223 acts either as an oncomiR promoting tumors or as a tumor suppressor in a context-dependent manner. Taken together, miR-223 can regulate tumorigenesis at multiple levels, including by suppressing the inflammatory tumor microenvironment and modulating malignancy of cancer cells. |
| Databáze: | OpenAIRE |
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