Interleukin-11 Modulates Th1/Th2 Cytokine Production from Activated CD4+T Cells
| Autor: | Judith L. Bliss, Andrew J. Dorner, William L. Trepicchio, Mary Bozza |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
CD4-Positive T-Lymphocytes
Time Factors medicine.medical_treatment T cell Immunology Dose-Response Relationship Immunologic Biology Lymphocyte Activation Proinflammatory cytokine Interferon-gamma Mice Th2 Cells Virology medicine Animals Humans Receptors Interleukin-11 Macrophage Interleukin-11 Receptor alpha Subunit IL-2 receptor Cells Cultured Cell Polarity Receptors Interleukin Cell Biology Th1 Cells Interleukin-11 Glycoprotein 130 Interleukin-12 Coculture Techniques Recombinant Proteins Cell biology Mice Inbred C57BL Cytokine medicine.anatomical_structure Cytokines Female Tumor necrosis factor alpha CD8 |
| Zdroj: | Journal of Interferon & Cytokine Research. 21:21-30 |
| ISSN: | 1557-7465 1079-9907 |
| DOI: | 10.1089/107999001459123 |
| Popis: | Recombinant human interleukin-11 (rHuIL-11) is a pleiotropic cytokine with effects on multiple cell types. rHuIL-11 reduces activated macrophage activity and downregulates production of proinflammatory mediators, such as tumor necrosis factor-alpha (TNF-alpha) and nitric oxide (NO). In vitro and in vivo, rHuIL-11 inhibits production of key immunostimulatory cytokines, including IL-12 and interferon-gamma (IFN-gamma). rHuIL-11 has recently demonstrated immunomodulatory activity to downregulate IFN-gamma production, increase IL-4 production, and reduce inflammatory tissue injury in a human psoriasis clinical trial. The cellular mechanisms of these effects are not fully elucidated. We demonstrate here that expression of gp130 and IL-11 receptor (IL-11R) alpha mRNA, components of the IL-11R complex, are detected in human and murine CD4(+) and CD8(+) lymphocytes, suggesting that rHuIL-11 can directly interact with T cells. In a cell culture model of murine T cell differentiation, rHuIL-11 acts to inhibit IL-2 production as well as IL-12-induced IFN-gamma production and enhances IL-4 and IL-10 production. rHuIL-11 had no effect on T cell proliferation. The ability of rHuIL-11 to modulate cytokine production from activated CD4(+) T cells provides a mechanism through which rHuIL-11 may ameliorate such inflammatory diseases as psoriasis. |
| Databáze: | OpenAIRE |
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