Gold‑manganese oxide nanocomposite suppresses hypoxia and augments pro-inflammatory cytokines in tumor associated macrophages
| Autor: | Hasimur Rahaman, Ramkrishna Pal, Mahuya Sengupta, Anupam Nath, Himadri Saikia, Sujit Kumar Ghosh, Leichombam Mohindro Singh, Ritwik Mazumder |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Fibrosarcoma Iron Immunology Nitric Oxide Prolyl Hydroxylases Nanocomposites Proinflammatory cytokine Nitric oxide Mice 03 medical and health sciences chemistry.chemical_compound Th2 Cells 0302 clinical medicine Tumor Microenvironment medicine Animals Immunology and Allergy Hypoxia Cells Cultured Pharmacology chemistry.chemical_classification Reactive oxygen species Tumor microenvironment Tumor hypoxia Macrophages Cell Differentiation Oxides Th1 Cells Hypoxia (medical) Phenotype Cell biology 030104 developmental biology Enzyme Manganese Compounds chemistry 030220 oncology & carcinogenesis Cytokines Gold Inflammation Mediators medicine.symptom Oxidation-Reduction |
| Zdroj: | International Immunopharmacology. 57:157-164 |
| ISSN: | 1567-5769 |
| DOI: | 10.1016/j.intimp.2018.02.021 |
| Popis: | The tumor microenvironment, essentially hypoxic, is sustained by the hypoxia inducing factor (HIF), released from the pro-tumorigenic tumor associated macrophages (TAMs), functionally identical to the M2 phenotype macrophages. Stability of HIF mainly depends on molecular oxygen and an iron-dependent enzyme prolyl hydroxylase, while its activity may be inhibited by high levels of reactive oxygen species and nitric oxide. The present work showcases a novel approach utilizing the anti-tumorigenic potential of a gold-manganese oxide nanocomposite material in the tumor microenvironment that affects tumor hypoxia, exploring the possibility of restoring the immunoregulatory nature of TAMs from their pro-tumorigenic state. Along with the biochemical markers, ELISA and FACS analyses have also confirmed the potential of these nanoparticles in reverting back the M2 phenotype of TAMs to their classically activated M1 phenotype. |
| Databáze: | OpenAIRE |
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