Association of CCR5 Δ32 deletion with early death in multiple sclerosis
| Autor: | Radhika Gade-Andavolu, James P. MacMurray, Masoud Rostamkhani, Wallace W. Tourtellotte, Li S C Cheng, David E. Comings, Lawrence A. Cone |
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| Rok vydání: | 2004 |
| Předmět: |
Central Nervous System
Male Multiple Sclerosis Genotype Receptors CCR5 T-Lymphocytes Biology Pathogenesis Predictive Value of Tests medicine Humans Genetic Predisposition to Disease Allele Survival rate Alleles Genetics (clinical) Sequence Deletion Multiple sclerosis Experimental autoimmune encephalomyelitis Hazard ratio Case-control study Prognosis medicine.disease Survival Rate Case-Control Studies Immunology Disease Progression Female |
| Zdroj: | Genetics in Medicine. 6:126-131 |
| ISSN: | 1098-3600 |
| Popis: | Purpose: The interaction between chemokines and their receptors is extremely important in controlling T cell migration into sites of CNS inflammation. Because trafficking of inflammatory T cells into the central nervous system (CNS) is a key player in the pathogenesis of multiple sclerosis (MS), we investigated the possible association of CCR5 Δ32 deletion in this disorder. Methods: DNA isolated from postmortem brain tissue samples of 132 patients with MS and from blood tissue samples of 163 gender and ethnicity-matched healthy controls was used to screen for the CCR5 Δ32 deletion allele. Results: An increased frequency of 32-bp deletion allele was found to be associated with early death (P = 0.00005) and with a progressive reduction in the years of survival (onset to death). The death hazard ratio of CCR5 with deletion versus no deletion was 2.12, suggesting that MS patients with the 32-bp deletion have twice the mortality rate of patients with the normal genotype. This effect was more significant in females (hazard ratio 3.58). Conclusion: A strong association of the CCR5 Δ32 deletion with early death could serve as a prognostic marker for MS. |
| Databáze: | OpenAIRE |
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