Carbon monoxide exposure in the urban environment: An insidious foe for the heart?
| Autor: | Cazorla, Olivier, Farah, C., Kleindienst, A., Bolea, G., Meyer, G., Gayrard, S., Geny, B., Obert, P., Sandré, T., Reboul, Cyril, Thireau, J., André, L., Richard, S. |
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| Přispěvatelé: | EA4278 Laboratoire de Pharm-Ecologie Cardiovasculaire (LaPEC), Avignon Université (AU), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie cardiovasculaire, Université Montpellier 1 (UM1)-IFR3, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie des adaptations cardiovasculaires à l'Exercice, CETIM-CERMAT, Institut de Chimie Organique et Analytique (ICOA), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Pulmonary and Respiratory Medicine
Hemoglobin binding Pathology medicine.medical_specialty Heart Diseases Urban Population Physiology Endogeny 030204 cardiovascular system & hematology Biology Pharmacology 03 medical and health sciences 0302 clinical medicine [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Biological property 11. Sustainability medicine Animals Humans Cardiac disorders ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences Air Pollutants Carbon Monoxide ECG General Neuroscience Environmental Exposure Carbon monoxide exposure 3. Good health Electrophysiological Phenomena Ion homeostasis Acute exposure [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Urban environment [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Respiratory Physiology and Neurobiology Respiratory Physiology and Neurobiology, Elsevier, 2012, 184 (2), pp.204-212. ⟨10.1016/j.resp.2012.06.010⟩ |
| ISSN: | 1569-9048 1878-1519 |
| DOI: | 10.1016/j.resp.2012.06.010⟩ |
| Popis: | International audience; Since Claude Bernard first demonstrated in the 19th century that carbon monoxide (CO) poisoning occurs through hemoglobin binding, CO has proven to be more than simply a toxic gas, and to possess complex biological properties. In this review, we highlight the dual nature of CO in cardiovascular function, from endogenous and therapeutic properties to harmful aspects. Focussing on exposure to low environmental CO levels, the most common but least studied form of exposure, we summarize the pathophysiological effects of CO in vivo and in vitro, from cardiac disorders to phenotypic remodelling of cardiomyocytes, based on clinical observations and experimental studies. While acute exposure to low CO levels is considered beneficial and cardioprotective, prolonged exposure appears deleterious, mainly due to alterations in redox status, ion homeostasis, intracellular Ca 2+ handling, and sympathovagal balance. We emphasize that, despite its fascinating therapeutic potential at low levels, regular exposure to CO may have significant consequences on cardiovascular health and must be considered a cardiovascular risk factor. |
| Databáze: | OpenAIRE |
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