Relationship between motion, using the GaitSmart (TM) system, and radiographic knee osteoarthritis: an explorative analysis in the IMI-APPROACH cohort
| Autor: | Diana Hodgins, Floris P J G Lafeber, Anne Karien Marijnissen, Francis Berenbaum, Margreet Kloppenburg, Eefje M van Helvoort, Ida K. Haugen, Francisco J. Blanco, Simon C. Mastbergen, M. Loef, Paco M J Welsing, Hans Guehring |
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| Přispěvatelé: | University Medical Center [Utrecht], Merck [Darmstadt], Leiden University Medical Center (LUMC), Universidade da Coruña, Diakonhjemmet Hospital, Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Gestionnaire, HAL Sorbonne Université 5, Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Radiography Osteoarthritis Severity of Illness Index Cohort Studies 03 medical and health sciences IMI-APPROACH 0302 clinical medicine Rheumatology Linear regression Humans Medicine Pharmacology (medical) Patient Reported Outcome Measures 030212 general & internal medicine Gait AcademicSubjects/MED00360 Aged 030203 arthritis & rheumatology [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system Principal Component Analysis Receiver operating characteristic business.industry Middle Aged Osteoarthritis Knee Clinical Science medicine.disease [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system Subchondral bone Cohort Physical therapy Female Patient-reported outcome Gait Analysis business |
| Zdroj: | Rheumatology (Oxford, England) Rheumatology Rheumatology, Oxford University Press (OUP), 2021, 60 (8), pp.3588-3597. ⟨10.1093/rheumatology/keaa809⟩ Rheumatology, 60(8), 3588-3597. OXFORD UNIV PRESS RUC. Repositorio da Universidade da Coruña instname Rheumatology, 2021, 60 (8), pp.3588-3597. ⟨10.1093/rheumatology/keaa809⟩ |
| ISSN: | 1462-0324 1460-2172 |
| DOI: | 10.1093/rheumatology/keaa809⟩ |
| Popis: | Objectives To assess underlying domains measured by GaitSmartTMparameters and whether these are additional to established OA markers including patient reported outcome measures (PROMs) and radiographic parameters, and to evaluate if GaitSmart analysis is related to the presence and severity of radiographic knee OA. Methods GaitSmart analysis was performed during baseline visits of participants of the APPROACH cohort (n = 297). Principal component analyses (PCA) were performed to explore structure in relationships between GaitSmart parameters alone and in addition to radiographic parameters and PROMs. Logistic and linear regression analyses were performed to analyse the relationship of GaitSmart with the presence (Kellgren and Lawrence grade ≥2 in at least one knee) and severity of radiographic OA (ROA). Results Two hundred and eighty-four successful GaitSmart analyses were performed. The PCA identified five underlying GaitSmart domains. Radiographic parameters and PROMs formed additional domains indicating that GaitSmart largely measures separate concepts. Several GaitSmart domains were related to the presence of ROA as well as the severity of joint damage in addition to demographics and PROMs with an area under the receiver operating characteristic curve of 0.724 and explained variances (adjusted R2) of 0.107, 0.132 and 0.147 for minimum joint space width, osteophyte area and mean subchondral bone density, respectively. Conclusions GaitSmart analysis provides additional information over established OA outcomes. GaitSmart parameters are also associated with the presence of ROA and extent of radiographic severity over demographics and PROMS. These results indicate that GaitsmartTM may be an additional outcome measure for the evaluation of OA. |
| Databáze: | OpenAIRE |
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