C-terminal anthranoyl–anthranilic acid derivatives and their evaluation on CCK receptors
| Autor: | Valentina Valenta, E. Luxich, Lucia Lassiani, Antonio Varnavas |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Stereochemistry
medicine.drug_class Dimer Guinea Pigs Pharmaceutical Science Carboxamide Ligands digestive system Cholecystokinin receptor chemistry.chemical_compound Drug Discovery Anthranilic acid medicine Animals ortho-Aminobenzoates Molecular Structure Ligand digestive oral and skin physiology Asperlicin Affinities Receptor Cholecystokinin B Rats Receptor Cholecystokinin A chemistry Cholecystokinin B receptor Receptors Cholecystokinin hormones hormone substitutes and hormone antagonists |
| Zdroj: | Il Farmaco. 55:293-302 |
| ISSN: | 0014-827X |
| DOI: | 10.1016/s0014-827x(00)00043-4 |
| Popis: | A series of C-terminal anthranoyl-anthranilic acid derivatives arising from a strict bond disconnection approach of asperlicin were synthesized and examined for their CCK receptor affinities. These compounds represent the second step of our investigation directed toward the search for alternative substructures of asperlicin as a starting point for the development of a new class of CCK ligands. The obtained micromolar affinities for CCK-A rather than CCK-B receptor confirm that the anthranilic acid dimer represents a useful template for the development of selective CCK-A receptor ligands. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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