Cartilage lesions in feline stifle joints - Associations with articular mineralizations and implications for osteoarthritis
| Autor: | Charles J. Ley, Antonia Corin, Alexandra Leijon, Cecilia Ley |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Cartilage
Articular Pathology medicine.medical_specialty 040301 veterinary sciences Radiography Osteoarthritis Meniscus (anatomy) Cat Diseases Menisci Tibial 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Synovitis medicine Animals 030203 arthritis & rheumatology General Veterinary business.industry Cartilage Synovial Membrane Histology 04 agricultural and veterinary sciences Anatomy medicine.disease Stifle medicine.anatomical_structure Cats Synovial membrane business Tomography X-Ray Computed Medial meniscus |
| Zdroj: | Research in veterinary science. 114 |
| ISSN: | 1532-2661 |
| Popis: | Feline stifle osteoarthritis (OA) is common, however little is known about the early stages of the disease. Furthermore, the importance of small articular mineralizations (AMs) in feline stifle OA is controversial. This study aimed to describe microscopic articular cartilage lesions and to investigate associations between cartilage lesions and AMs, synovitis, osteochondral junction findings and subchondral bone sclerosis. Stifles of 29 cats, aged 1-23years and euthanized for reasons other than stifle disease, were examined. Osteochondral tissue and synovial membrane changes were histologically evaluated. Computed tomography and radiography were used for evaluation of AMs. Global cartilage scores (GCS, n=28) were summarized and joints assigned a histologic OA grade. Minimal to mild histologic OA was seen in 24/28 joints. In 27/29 joints tibial cartilage lesions were seen, whereas femoral lesions were only seen in two joints. Articular mineralizations were detected in 13/29 joints, 11 were small and 12 were located entirely within the medial meniscus. There was no association between GCS and presence or volumes of AMs. However, higher GCS was associated with synovitis (P=0.001) and age (P |
| Databáze: | OpenAIRE |
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