Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3' group chirality

Autor:	Dickinson Roger Peter, M. Frank Burslem, M. Jonathan Fray
Rok vydání:	2001
Předmět:	chemistry.chemical_classification Hydroxamic acid biology Stereochemistry Carboxylic acid Organic Chemistry Clinical Biochemistry Pharmaceutical Science Matrix metalloproteinase Matrix Metalloproteinase Inhibitors Hydroxamic Acids Biochemistry Chemical synthesis chemistry.chemical_compound Structure-Activity Relationship Dicarboxylic acid chemistry Enzyme inhibitor Drug Discovery biology.protein Molecular Medicine Protease Inhibitors Chirality (chemistry) Selectivity Molecular Biology
Zdroj:	Bioorganicmedicinal chemistry letters. 11(4)
ISSN:	0960-894X
Popis:	Structure–activity relationships are described for a series of succinyl hydroxamic acids 1a–o and their carboxylic acid analogues 2a–o as inhibitors of matrix metalloproteases MMP-3 and MMP-2. For this series (P1′=(CH2)3Ph, P2′=t-Bu) selectivity for the inhibition of MMP-2 was found to be strongly dependent on P3′.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9d62c46bfde7ebed7b2caed3939986 https://pubmed.ncbi.nlm.nih.gov/11229773 Zobrazit plný text záznamu Full Text from ScienceDirect