Early-life seizures modify behavioral response to ultrasonic vocalization playback in adult rats
| Autor: | Logan J. Bigelow, Catherine Fiset, Jack H.M. Jarvis, Sarah Macleod, Markus Wöhr, Tim A. Benke, Paul B. Bernard |
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| Rok vydání: | 2021 |
| Předmět: |
Male
SEX-DIFFERENCES Autism Spectrum Disorder Autism Clinical Neurology CHILDREN SINGLE EPISODE LABORATORY RATS DEVELOPING BRAIN Rats Sprague-Dawley Behavioral Neuroscience Seizures NEONATAL SEIZURES Animals Humans Ultrasonics C-FOS EXPRESSION Psychiatry Science & Technology Communication Ultrasonic vocalization AUTISM SPECTRUM DISORDER STATUS EPILEPTICUS Seizure Rats Neurology Kainic acid Female Neurology (clinical) Neurosciences & Neurology Vocalization Animal Life Sciences & Biomedicine Behavioral Sciences 22 KHZ |
| Zdroj: | Epilepsybehavior : EB. 127 |
| ISSN: | 1525-5069 |
| Popis: | Early-life seizures (ELS) are associated with autism spectrum disorder (ASD); however, due to a lack of effective treatments for ELS, it is not clear whether ELS plays a causal role, potentiates the ASD phenotype, or is the result of a common pathophysiology. Deficits in communications are a core feature of ASD. To isolate the impact of ELS on communication, we probed the behavioral consequences of a single episode of kainic acid-induced early-life seizures (KA-ELS) in male and female Sprague-Dawley (CD) rats. Deficits in auditory communication were observed in adult male rats as assessed by behavioral response to ultrasonic vocalization (USV) playback. Ultrasonic vocalizations are classified into two major categories - 50-kHz (positive) calls and 22-kHz (aversive) calls. Behavioral response was assessed via rat preference for different USV playback in a radial arm maze. Response to 22-kHz calls was not impacted by ELS while response to 50-kHz calls was impacted. All rats demonstrated positional preference for the arms adjacent to where 50-kHz calls were playing compared to background noise; however, male ELS rats demonstrated a greater positional preference for the arms adjacent to where 50-kHz calls were playing compared to male control rats. These studies demonstrate that responses to socially relevant auditory cues are chronically altered in adult male rats following a single episode of ELS. We speculate that these changes contribute to previously reported social deficits associated with ELS. ispartof: EPILEPSY & BEHAVIOR vol:127 ispartof: location:United States status: published |
| Databáze: | OpenAIRE |
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