Clinical significance of skip lymph-node metastasis in pN1 gastric-cancer patients after curative surgery
| Autor: | Li Zhang, Huifang Liu, Wen-Ting He, Jingyu Deng, Jin-Yuan Liu, Han Liang, Wei-Lin Sun, Yan Wang, Nannan Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Gastroenterology Metastasis 03 medical and health sciences 0302 clinical medicine medicine.artery Internal medicine medicine metastasis Clinical significance Survival rate Survival analysis Common hepatic artery business.industry Stomach Cancer Hepatoduodenal ligament Perigastric medicine.disease medicine.anatomical_structure multivariate analysis 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Original Article prognosis business neoplasm |
| Zdroj: | Gastroenterology Report |
| ISSN: | 2052-0034 |
| Popis: | Background In addition to the stepwise manner of lymph-node metastasis from the primary tumour, the skip lymph-node metastasis (SLNM) was identified as a low-incidence metastasis of gastric cancer (GC). So far, both the mechanism and outcome of SLNM have not been elucidated completely. The purpose of this study was to analyse the clinical significance and the potential mechanism of SLNM in GC patients who had lymph-node metastasis. Methods Clinicopathological data and follow-up information of 505 GC patients who had lymph-node metastasis were analysed to demonstrate the significance of SLNM in evaluating the prognostic outcome. According to the pathological results, all GC patients who had lymph-node metastasis were categorized into three groups: patients with the perigastric lymph-node metastasis, patients with the perigastric and extragastric lymph-node metastasis and patients with SLNM. Results: Among the 505 GC patients who had lymph-node metastasis, 24 (4.8%) had pathologically identified SLNM. The location of lymph-node metastasis was not significantly associated with 5-year survival rate and overall survival (OS) (P = 0.194). The stratified survival analysis results showed that the status of SLNM was significantly associated with the OS in patients with pN1 GC (P = 0.001). The median OS was significantly shorter in 19 pN1 GC patients with SLNM than in 100 patients with perigastric lymph-node metastasis (P |
| Databáze: | OpenAIRE |
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