Nuclear magnetic resonance-based metabolomics reveals that dairy protein fractions affect urinary urea excretion differently in overweight adolescents
| Autor: | Hong Zheng, Kim F. Michaelsen, Trine Kastrup Dalsgaard, Christian Mølgaard, Karina Arnberg, Anni Larnkjær, Christian Clement Yde, Hanne C. Bertram |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
animal structures
food.ingredient Urinary system whey Urine Overweight Biochemistry casein Industrial and Manufacturing Engineering Excretion chemistry.chemical_compound fluids and secretions Metabolomics food milk protein Casein Skimmed milk medicine Urea Food science citrate food and beverages General Chemistry chemistry medicine.symptom Food Science Biotechnology |
| Zdroj: | Zheng, H, Yde, C C, Dalsgaard, T K, Arnberg, K, Moelgaard, C, Michaelsen, K F, Larnkjær, A & Bertram, H C S 2015, ' Nuclear magnetic resonance-based metabolomics reveals that dairy protein fractions affect urinary urea excretion differently in overweight adolescents ', European Food Research and Technology, vol. 240, no. 3, pp. 489–497 . https://doi.org/10.1007/s00217-014-2347-0 |
| DOI: | 10.1007/s00217-014-2347-0 |
| Popis: | Dairy proteins are an important part of our diet, and recently, there is considerable focus on understanding the effects of the two major dairy proteins fractions constituted by casein and whey. In the present study, the impact of a dietary intervention with casein, whey, and skim milk was investigated by using NMR-based urine metabolomics. Overweight adolescents (n = 192; age = 12–15 years; BMI = 25.4 ± 2.3 kg/m2) were randomly assigned to 1 L/day of casein (citrate content: 3.27 mol/L), whey (citrate content: 0.04 mol/L), skim milk, or water for 12 weeks. A significant increase in the urinary excretion of urea was found after the 12-week casein and skim milk interventions, while the 12-week whey intervention had no significant effect on the urea excretion. In addition, NMR-based metabolomics revealed a decreased urinary citrate excretion in the whey group and thereby demonstrated its potential to disclosure exposure effects. In conclusion, the present study demonstrates that casein and whey proteins impact urinary urea excretion differently. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|