Thirteen cancers associated with HIV infection in a Black South African cancer patient population (1995‐2016)

Autor: Mazvita Sengayi‐Muchengeti, Elvira Singh, Wenlong Carl Chen, Debbie Bradshaw, Chantal Babb de Villiers, Robert Newton, Tim Waterboer, Christopher G Mathew, Freddy Sitas
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Cancer. 152:183-194
ISSN: 1097-0215
0020-7136
DOI: 10.1002/ijc.34236
Popis: South Africa's HIV epidemic has evolved over time in terms of numbers of people living with HIV, access to antiretroviral treatment (ART) and age. These changes have profoundly influenced local cancer patterns. The Johannesburg Cancer Study has, over a period of 22 years (1995-2016), recruited over 20 000 incident black cancer patients who consented to provide answers to a questionnaire and blood samples (serum, DNA). This has presented a unique opportunity to examine the evolving association of HIV with cancer in Africa. We used logistic regression models to explore case-control associations between specific cancers and HIV, using participants with non-infection related cancers as controls. Using data of 20 835 cancer patients with confirmed HIV status, we found the following cancers to be associated with HIV: Kaposi's sarcoma (OR
Databáze: OpenAIRE
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